Complexity and Handling of huge data is a crucial target for all management systems. Databases are the backbone, central and core component of a computer application to store data in a logical way, which define the structure and mechanism for manipulation of data. Many Databases are available for handling and saving huge data including commercial and non-commercial like Microsoft SQL Server, Oracle Database, and MYSQL etc. Many vendors are working on modern techniques of databases spatiotemporal, object-relational, parallel databases etc. This novel research evaluates the comparative study and execution performance of top three databases according to their particular scenario and situation, after reading the paper the computer-related experts especially developers easily judge, which database is most reliable in particular scenario, choosing the right decision for development of huge computer applications for hospitals, banks, and industries.