You can change yoru string variable case using ToLower() or ToUpper() method.
ToLower() method change characters into lower cases. But ToLower method uses your system's current regional settings. And if your culture settings adjusted for Turkish, for a string variable with "INDIGO" value the result will be "indigo". Therefore you must use System.Globalization.CultureInfo class to adjust for the desirable culture.
s.ToLower(
New CultureInfo("en-US"));
You can dicover all the culture names on the link below.
You can use s.ToUpper() and s.ToUpper(New CultureInfo("en-US")) to change character cases into lower.